Renin Angiotensin System (RAS) and Immune Function Outline

1. Introduction
2. The renin-angiotensin system (RAS).
3. Historical perspective
4. Current knowledge
5. Immune function
6. Historical perspective
7. Current knowledge
8. Protection against infectious disease
9. Pathologies of the immune system
10. disease associated damage caused by immune responses

normal concentration of T cells in blood vs concentration in immune disorders.

1. autoimmune disorders
2. statistics on incidence and prevalence

women are twice as likely to have autoimmune disorders

ii.economic costs

1. Interactions of the RAS with the immune system
2. Angiotensin II (Ang II) activation of T cells
3. Ang II actions on other immune cells
4. Pathophysiological interactions of the RAS with the immune system
   1. Inflammatory actions
   2. Autoimmune disease
5. Pathophysiology
6. Current therapeutic approaches

III.        The RAS and lupus erythematosus (lupus)

1. Specific interactions of the RAS with T cells
   1. Promotion of autoimmune function
   2. Promotion of lupus
2. Strategies for blockade of the RAS as a therapeutic modality for treatment of lupus
   1. Blockade of Ang II production
      1. Renin inhibitors
      2. ACE inhibitors
   2. Blockade of AT₁ Ang II receptor subtype
   3. Activation of AT₂ Ang II receptor subtype with AT₂ receptor agonists C21 compound 21
   4. Activation of mas (Ang 1-7 receptor)
      1. Promotion of Ang 1-7 formation
      2. Treatment with agonists of mas
      3. Summary and Conclusions

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