I need a review of genetics in gynecologycal cancers – endometrial, ovarian and breast. Please describe inherited cancer syndromes – lynch, brca1, brca 2, li fraumeni, cowden and others and implications on gynecological cancer – relative risks to general population,epidemiology, age distribution and implications on histopathology, staging, prognosis and treatment. Describe guidelines on inherited cancer syndromes screening, indications for genetic testing and preventative measures in women with confirmed inherited cancer syndromes – screening reccomendations ad prophylactic measures ( mastectomy, adnexectomy, tubectomy). Use nccn guidelines. Focus of the article is on gyn cancers others than breast. Use uptodate.com, relevant pubmed articles and nccn guidelines.
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