IV Injections: Stability, compatibility, Incompatibility and Mode of Administration

 

Table 1: Securon 2.5mg/ml Verapamil Hydrochloride

NameSecuron 2.5mg/ml aqueous solution for injection Verapamil Hydrochloride
StabilitySINGLE USE
IncompatibilityAcetylsalicylic  acid, alpha blockers, Antiarrhythmics, Alkaline Solutions
CompatibilityWater for injections; Sodium chloride (8.5mg/ml); Hydrochloric acid 10% as pH adjuster.
AdministrationSlow INTRAVENOUS INJECTION (Gray et al., 2016).

 

Table 2: Acetylcysteine Injection 200mg/ml Acetylcysteine

NameAcetylcysteine Injection 200mg/ml Acetylcysteine
StabilitySINGLE USE
IncompatibilityRUBBER AND METALS (iron, copper and Nickel)

Change of color to light purple

CompatibilityDisodium Edetate

Glucose 5%

Nitrogen Gas

Water for Injection

Sodium Chloride 0.9%;

Sodium Hydroxide for PH adjustment (Gray et al. 2016).

AdministrationINTRAVENOUS infusion.

 

Table 3: Adenocor 3mg/mL solution for injection: Adenosine

NameAdenocor 3mg/mL solution for injection Adenosine
StabilitySINGLE USE
IncompatibilityNOT known. DO NOT MIX WITH OTHER MEDICINAL
CompatibilityWater for Injection; Sodium Chloride 0.9%
AdministrationRAPID IV Injection (Gray et al., 2016).

 

Table 4: Diltiazem Hydrochloride Injection

NameDiltiazem Hydrochloride Injection
StabilitySINGLE USE
IncompatibilityDO NOT mix with other drugs in the administration container.

DO NOT co-infuse in the same IV line with other drugs.

VISUALLY inspect the drug for particulate matter and discoloration

CompatibilityDextrose 5% injections

Sodium Chloride 0.9% Injection

Normal saline

Dextrose 5% + Sodium Chloride 0.9% injection (Gray et al., 2016).

AdministrationRAPID IV INJECTION (preferable) and CONTINOUS IV INFUSION

 

Table 5: Gentamicin Sandoz

NameGentamicin Sandoz 40 mg/80 mg ampoules
StabilitySINGLE USE
IncompatibilityDO NOT MIX WITH OTHER DRUGS before injection

DO NOT COADMINSTER with other drugs

CompatibilitySodium metabisulphite

Sodium hydroxide

Disodium edetate

Methyl; hydroxybenzoate

Sulphuric acid (2.5N)

Propryl hydroxybenzoate

Water for Injections (Trissel & American Society of Health-system Pharmacists, 2011).

AdministrationIM INJECTION (preferable) or SLOW IV (when IM is not feasible).

 

Table 6: Ephedrine Hydrochloride

NameEphedrine Hydrochloride 30mg in 1ml Solution for Injection
StabilitySINGLE USE.
IncompatibilityAnionic salts such as carbonates, phosphates and acetates.
CompatibilityWater for Injections
AdministrationSLOW INTRAVENOUS INJECTION.

 

Table 7: Metronidazole Fresenius solution for infusion

NameMetronidazole Fresenius solution for infusion (1ml contains 5mg metronidazole; each 100ml vial contains 500mg metronidazole)
StabilityDiscard after SINGLE USE.
IncompatibilityDO NOT mix with other medical
CompatibilityDisodium phosphate dodecahydrate

Citric acid monohydrate

Glucose/sodium chloride

0.9% Sodium chloride solution

5% Glucose solution

Potassium Chloride solutions (20mmol and 40mmol)

Ringer’s solution

AdministrationINTRAVENOUS INFUSION at an approximate rate of 5 ml/min (Trissel & American Society of Health-system Pharmacists, 2011).

 

Table 8: Flolan: Epoprostenol Sodium

NameFlolan: Epoprostenol Sodium
StabilitySINGLE USE. Refrigerate reconstituted solutions at 2-80C for not more than 40hrs
IncompatibilityDO NOT mix with other medicinal
CompatibilityPowder for solution for infusions:

NaOH for pH adjustment; Glycine; Sodium chloride; Mannitol

Solvent for parenteral use:

Water for injection

Sodium hydroxide for pH adjustment

Sodium chloride

AdministrationCONTINOUS INTRAVENOUS INFUSION via a central venous catheter using an AMBULATORY Fusion PUMP.

DO NOT administer as a BOLUS INJECTION (Gray et al., 2016).

 

Table 9: Meronem IV

NameMeronem IV
StabilityEach vial is for SINGLE USE ONLY
IncompatibilityDo NOT mix with or add other medicinal
CompatibilityAnhydrous sodium carbonate

5% Glucose with 0.15% Potassium Chloride solution

5% Glucose solution + 0.02 Sodium bicarbonate

0.9% sodium chloride solution

5% or 10% Glucose solution

5% Glucose solution + 0.9% Sodium Chloride

Mannitol 2.5% or 10% solution

5% glucose with 0.225% Sodium Chloride Solution.

AdministrationINTREAVENOUS INFUSION over 15-30mins (preferable)

IV INJECTION up to 1g doses over approximately 5 minutes

 

Table 10: ARIXTRA Fondaparinux Sodium (Fondaparinux)

NameARIXTRA Fondaparinux Sodium (Fondaparinux)
StabilitySINGLE USE. Store for up to 24hrs at room temperatures.
IncompatibilityDo NOT mix with other medicinal products.
CompatibilityPhysiologic sodium chloride (0.9%)

Water for Injection

Hydrochloric acid or Sodium Hydroxide for pH adjustment if necessary

AdministrationSUBCUTANEOUS administration and INTRAVENOUS administration

 

Table 11: Rocephin

NameRocephin
StabilitySINGLE USE
IncompatibilityHartmann’s or Ringer’s solution (calcium containing solutions)

Do not mix or co-administer with other medicinal

CompatibilityWater for Injections

Sodium chloride 0.45% + Glucose 2.5%

Sodium chloride 0.9%

Glucose 5% or 10%

Dextran 6% in glucose 5%

Hydroxyethyl starch 6-10% (Gray et al., 2016).

AdministrationINTRAMUSCULAR injection or INTRAVENOUS injection or INTRAVENOUS infusion (Gray et al., 2016).

 

Table 12: Esmeron

NameEsmeron: Esmeron 10mg/ml, solution for injection
StabilitySINGLE USE
IncompatibilityThe FOLLOWING drugs: Prednisolone sodium succinate, hydrocortisone sodium succinate, Amoxicillin, Amphotericin, azathioprine, cefazolin, cloxacillin, dexamethasone, diazepam, erythromycin, famotidine, furosemide, insulin, methohexital, methylprednisolone, enoximone, thiopental, trimethoprim, vancomycin, and Intralipid (Trissel & American Society of Health-system Pharmacists, 2011).

If the drug is to be administered with other drugs using the same IV line, the line must be adequately flushed (using 0.9% NaCl).

CompatibilitySodium acetate (for pH adjustment)

Sodium chloride

Water for Injection

Acetic acid (for pH adjustments)

AdministrationIV BOLUS injection or INTRAVENOUS continuous infusion

 

Table 13: Intratect

NameIntratect 100g/l solution for infusion
StabilitySINGLE USE
IncompatibilityDo NOT mix with other medicinal products
CompatibilityGlycine; Water for Injections
AdministrationINTRAVENOUS infusion.

 

Table 14: Keppra

NameKeppra 100mg/ml concentrate for solution for infusion
StabilitySINGLE USE
IncompatibilityNOT indicated
CompatibilityLevetiracetam 500mg

Water for Injection

Physiological NaCl

Sodium acetate trihydrate

Glacial Acetic Acid as a 10% (v/v) Solution

AdministrationINTRAVENOUS use only

 

Table 15: Trandate Labetalol

NameTrandate Labetalol
StabilitySINGLE USE.
IncompatibilitySodium bicarbonate injection BP 4.2% W/V
CompatibilityBeta-blocking drugs

Compound Sodium Lactate BP

0.18% Sodium Chloride + 4% Dextrose

5% Dextrose BP

Water for Injection

0.3% Potassium Chloride + 5% Dextrose BP.

AdministrationINTRAVENOUS bolus Injection or INTRAVENOUS Infusion

 

Table 16: Phenytoin Hikma

NamePhenytoin Hikma 50mg/ml solution for injection (phenytoin sodium)
StabilitySINGLE use ONLY
IncompatibilityDo NOT mix with other Medicinal
CompatibilityPropylene glycol

Ethanol (96%)

Sodium Hydroxide for pH adjustment

Water for Injection

AdministrationSLOW INTRAVENOUS infusion (Gray et al., 2016).

 

Table 17: Aggrastat Concentrate solution

NameAggrastat Concentrate solution for IV infusion equivalent to 0.25mg/ml Tirofiban base
StabilitySINGLE USE. Storage should NOT exceed 24hrs at 2-80C.
IncompatibilityDiazepam
CompatibilitySodium citrate dihydrate

Sodium chloride

Citric acid anhydrous

Hydrochloric acid or Sodium hydroxide for pH adjustment

Water for injection

AdministrationSHOULD only be administered INTRAVESOUSLY with unfractionated heparin (recommended).

 

Table 18: Mikacin

NameMikacin: Amikacin Sulphate for parenteral use
StabilitySINGLE USE.
IncompatibilityDo NOT MIX or Co-administer with contraindicated antibiotics
CompatibilitySodium metabisulphite; Sodium citrate; Sodium chloride injection; 5% Dextrose; Compound Sodium Lactate
AdministrationINTRAMUSCULAR route (preferred)

INTRAVENOUS slow bolus (2-3mins)

INTRAVENOUS infusion (0.25% over 30min)

IRRIGATION solution (Trissel & American Society of Health-system Pharmacists, 2011).

 

Table 19: Dopamine

NameDopamine 40mg/ml sterile concentrate
StabilitySINGLE USE. Store for up to 48hrs
IncompatibilityAlkaline IV solutions.

Admixtures containing or oxacillin sodium, cephalothin sodium neutral, gentamicin sulfate, or cephalothin sodium.

Ampicillin + Dopamine in 5% glucose solution

Dopamine + amphotericin B in glucose 5% solution

CompatibilitySodium metabisulphite

Water for injections

AdministrationINTRAVENOUS administration.

 

Table 20: Levobupivacaine

NameLevobupivacaine
StabilitySINGLE USE.
IncompatibilityAlkaline solutions; Other medications NOT specified
CompatibilityWater for Injections; Sodium hydroxide

Sodium chloride; Hydrochloric acid

AdministrationEPIDURAL bolus or Continuous slow EPIDURAL INFUSION or IV BOLUS.

 

Table 21: Bactrim for infusion

NameBactrim for infusion
StabilitySINGLE use.
IncompatibilityProducts that lower the pH below 8.

Levulose 5%, Hartmann’s solution and Sodium bicarbonate 1.4%

CompatibilityPropylene Glycol, Trometahmine

Sodium chloride 0.9%, Dextrose 5% and 10%

Sodium chloride 0.45% + Dextrose 2.5%,

Ringer’s solution (USP XVIII)

Sodium Hydroxide, Sodium Metabisulphate, Ethanol, Water for Injection

Xylitol 10%, Macrodex (dextran 70.6% in dextrose 5%),

AdministrationINTRAVENOUS administration.

 

Table 22: Piperacillin/Tazobactam Sandoz

NamePiperacillin/Tazobactam Sandoz 4.5g powder for solution for injection or infusion
StabilitySINGLE USE.
IncompatibilityAminoglycosides; SHOULD NOT be mixed with other medicinal in the infusions; Ringer’s solution and Hartmann’s solution; Blood products or albumin hydrolysates
CompatibilityWater for Injection; Sodium Chloride 9mg/ml (0.9%) solution

Glucose 50mg/ml (5%) solution in Water for Injection

Glucose 50mg/ml (5%) solution in NaCl 9mg/ml (0.9%) solution

Dextran (grade 40) 60mg/ml (6%) solution of Sodium Chloride 0.9% solution (Gray et al., 2016).

AdministrationINTRAVENOUS BOLUS  (3-5mins) or IV INFUSION (20-30mins).

 

Table 23: Vancomycin Hydrochloride for Injection

NameVancomycin Hydrochloride for Injection, USP. Fliptop Vial for IV
StabilityFOR SINGLE USE.
IncompatibilityDo NOT mix with other medicinal because of its low Ph
CompatibilitySterile Injection Water

5% Dextrose + Lactated Ringer’s Injection

5% Dextrose Injection USP

5% Dextrose + 0.9% Sodium Chloride Injection, USP

0.9% Sodium Chloride injection, USP

Lactated Ringer’s Injection, USP

Normosol-M and 5% Dextrose

ISOLYTE E

AdministrationINTRAVENOUS administration OR ORAL use.

 

Table 24: Lanoxin Injection (digoxin)

NameLanoxin Injection (digoxin)
StabilitySINGLE USE
IncompatibilityNOT Known. DO NOT mix or co-administer with other medicinal.
CompatibilityEthanol; Propylene Glycol; Citric acid Minohydrate; Sodium phosphate anhydrous or sodium phosphate; Water for Injections

Sodium Chloride IV infusion, BP 0.9% w/v; Sodium Chloride NaCl (0.18% w/v) + Glucose (4% w/v) IV Infusion, BP

AdministrationFor INTRAVENOUS USE only.

 

Table 25: ZOFRAN (Ondansetron)

NameZOFRAN (Ondansetron)
StabilitySINGLE IV DOSE.
IncompatibilityDO NOT mix or co-administer with other medicinal unless specified.
CompatibilitySodium chloride, Citric acid monohydrate, Water for injections, and Sodium citrate dihydrate

Glucose IV infusion BP 5% w/v

Potassium chloride 0.3% w/v + Sodium chloride 0.9% w/v IV infusion BP

Sodium Chloride IV infusion BP 0.9% w/v

Mannitol IV infusion BP 10% w/v

Ringer’s IV infusion

Potassium Chloride 0.3% w/v + Glucose 5% w/v Infusion BP

Compatible drugs include: Cisplatin, 5-flourouracil, carboplatin, etoposide, ceftazidime, cyclophosphamide, doxorubicin, dexamethasone (Gray, 2009).

AdministrationSLOW INTRAVENOUS injection or INTRAVENOUS infusion

 

Table 26: NovoSeven

NameNovoSeven 1mg, 2mg, 5mg and 8mg powder and solvent for solution for injection
StabilitySINGLE USE.
IncompatibilityNEVER MIX with other infusion solutions.

Do NOT give in a drip.

CompatibilityPowder

Sodium Chloride, Methionine, Mannitol, calcium chloride dehydrate, Glycylglycine, Polysorbate 80, Sucrose, Sodium hydroxide and hydrochloric acid for adjusting pH

Solvent

Water for injections, Histidine

Sodium hydroxide or hydrochloric acid for adjusting pH

AdministrationBOLUS INJECTION (recommended) and CONTINOUS Infusions

 

Table 27: Nimbex: Cisatracurium besylate

NameNimbex: Cisatracurium besylate
StabilitySINGLE USE
IncompatibilityLactated Ringer’s injection

Drugs: Ketorolac tremetamol or propofol injectable emulsion

CompatibilityWater for Injections

Benzene sulfonic acid

Dextrose (5% w/v) IV infusion

Sodium Chloride (0.9% w/v) IV infusion

Sodium chloride (0.18% w/v) + dextrose (4% w/v) IV infusion

Sodium Chloride (0.45% w/v) + dextrose (2.5% w/v) IV infusion.

Drugs: droperidol, midazolam hydrochloride, alfentanil hydrochloride, fentanyl citrate, sufentanil citrate

AdministrationINTRAVENOUS infusion and INTRAVENOUS bolus injection

 

Table 28: Fentanyl-Hameln 50mcg/ml Injection

NameFentanyl-Hameln 50mcg/ml Injection
StabilitySINGLE USE. Stability for 24hrs at 250C after dilution.
IncompatibilityNOT to be mixed with other medicinal.

Check compatibility before administration with other drugs.

Drugs: Pentobarbital sodium, methohexal sodium, thiopental sodium and nafcillin

CompatibilityWater for injections

Physiologic sodium chloride

Hydrochloric acid or Sodium Hydroxide for pH adjustment

AdministrationSLOW IV BOLUS injection and BOLUS INTRAVENOUS injection

 

Table 29: Curam

NameCuram 1.2g IV- powder for solution for injection/infusion
StabilitySINGLE USE only
IncompatibilityAmino acid solutions; Lipid emulsions; Blood and glucose solutions
CompatibilityNOT indicated
AdministrationINTRAVENOUS Injection and INTRAVENOUS infusion

 

References

Gray, A. H. (2009). Injectable drugs pocket companion. London: Pharmaceutical; Press.

Gray, A. H., Wright, J., Bruce, L., & Oakley, J. (2016). Clinical pharmacy: pocket companion. London: Pharmaceutical Press. Print Book: English

Trissel, L. A., & American Society of Health-system Pharmacists. (2011). Handbook on injectable drugs. Bethesda, M.D.: American Society of Health-System Pharmaceutical

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