- Find, cite, and briefly summarize a research study that demonstrates how a specific compound (i.e. molecule, chemical, hormone, neurotransmitter, xenobiotic) inhibits one element of male hormone physiology anywhere from influencing the hypothalamus or pituitary, to peripheral conversion. Try not to use compounds discussed during the lectures. Examples might include nutrient deficiencies (zinc, magnesium, vitamin K, etc), heavy metal exposure, cytokine influence, LPS, or even psychosomatic influences (i.e. are there studies demonstrating how one’s perception might influence hormones?). Areas to also consider are what up- or down-regulates certain enzymes (i.e. aromatase, 5a-reductase, etc.)?
- Please see how below how another student formatted their short response with statistics, as this is master’s level.
Example from another topic:
I found an interesting study from Fahrenholtz et al. (2018) analyzing within-day energy balance (WDEB) in female athletes, either with menstrual dysfunction (MD, n = 15) or eumenorrhea (n = 10). A 7-day energy expenditure and dietary intake data was analyzed. Every hour, various parameters were measured, including RMR, body composition by dual-energy X-ray absorptiometry, blood plasma analysis, and WDEB calculations. It was observed that athletes with MD had increased hours in a catabolic state. Interestingly, athletes that had hours within a calorie deficiency of <0 kcal and <-300 kcal had positive correlation with cortisol (r = 0.442, P = .027, r = .463, P = .019) and was negatively correlation with RMRratio (r = −.487, P = .013, r = −.472, P = .018). Additionally, MD athletes spend more time with insufficient blood glucose levels which has negative consequences on the hypothalamic-pituitary-gonadal axis, having additional impacts on hormones like estradiol.
- Here are a list of articles from this week’s class.
- APA peer reviewed, primary materials from https://www.ncbi.nlm.nih.gov or information from the ones listed (if relevant) is fine.
